Other Names: Grifola frondos

The maitake mushroom, also known as Grifola frondos, is a well-known mushroom and adapotgen that is renowned for its immune system supporting properties. Additionally, maitake is known for supporting biological processes that optimizes pH and helps the body respond in a healthy manner to stress. By promoting adequate interferon and interleukin levels in the body, two primary immune system regulators, maitake also supports healthy skin by supporting the immune system’s ability to naturally combat harmful invaders.

Maitake has also been shown through research to be useful at promoting the body’s ability to naturally protect itself from oxidative stress and free radicals. It supports natural defenses that protect cells in the body. Furthermore, this extract has the ability to support cellular health, which helps the body combat harmful toxins that could cause cell death. Research suggests that it also promotes natural defenses that help protect the body. It has the ability to support proper circulatory system function as well, which is essential for healthy cholesterol and blood pressure levels already in the healthy range.

The maitake mushroom extract is very helpful at supporting the immune system because it is an excellent source of antioxidants. In addition, this particular extract also contains proteins, minerals, vitamins, amino acids, fiber and carbohydrates that promote cellular health, which supports clear and healthy skin. As the body needs rich sources of healthy nutrients, taking the maitake mushroom extract can support overall health.

Studies on Maitake Mushroom:

  1. Wu MJ, Cheng TL, Cheng SY, Lian TW, Wang L, Chiou SY. Immunomodulatory properties of Grifola frondosa in submerged culture. J Agric Food Chem. 2006 Apr 19;54(8):2906-14.
  2. Huyan T, Li Q, Yang H, Jin ML, Zhang MJ, Ye LJ, Li J, Huang QS, Yin DC. Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells. Carbohydr Polym. 2014 Jan 30;101:819-27. doi: 10.1016/j.carbpol.2013.10.021. Epub 2013 Oct 12.
  3. Terakawa N, Matsui Y, Satoi S, Yanagimoto H, Takahashi K, Yamamoto T, Yamao J, Takai S, Kwon AH, Kamiyama Y. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Nutr Cancer. 2008;60(5):643-51.
  4. Vaclav Vetvicka and Jana Vetvickova. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb; 2(2): 14.

Other research:

  1. Postemsky PD, Curvetto NR. Submerged Culture of Grifola gargal and G. sordulenta (Higher Basidiomycetes) from Argentina as a Source of Mycelia with Antioxidant Activity. Int J Med Mushrooms. 2015;17(1):65-76.
  2. Postemsky P, Curvetto N. Enhancement of wheat grain antioxidant activity by solid state fermentation with Grifola spp. J Med Food. 2014 May;17(5):543-9. doi: 10.1089/jmf.2013.0108. Epub 2014 Feb 19.
  3. Mao G, Zou Y, Feng W, Wang W, Zhao T, Ye C, Zhu Y, Wu X, Yang L, Wu X. Extraction, preliminary characterization and antioxidant activity of Se-enriched Maitake polysaccharide. Carbohydr Polym. 2014 Jan 30;101:213-9. doi: 10.1016/j.carbpol.2013.09.034. Epub 2013 Sep 21.
  4. Lei H, Zhang M, Wang Q, Guo S, Han J, Sun H, Wu W. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-81.
  5. Chen GT, Ma XM, Liu ST, Liao YL, Zhao GQ. Isolation, purification and antioxidant activities of polysaccharides from Grifola frondosa. Carbohydr Polym. 2012 Jun 5;89(1):61-6. doi: 10.1016/j.carbpol.2012.02.045. Epub 2012 Feb 25.
  6. Yeh JY, Hsieh LH, Wu KT, Tsai CF. Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake). Molecules. 2011 Apr 15;16(4):3197-211. doi: 10.3390/molecules16043197.
  7. Zhang Y, Mills GL, Nair MG. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J Agric Food Chem. 2002 Dec 18;50(26):7581-5.
  8. Kodama N, Murata Y, Nanba H. Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. J Med Food. 2004 Summer;7(2):141-5.
  9. Sato M, Tokuji Y, Yoneyama S, Fujii-Akiyama K, Kinoshita M, Chiji H, Ohnishi M. Effect of dietary Maitake (Grifola frondosa) mushrooms on plasma cholesterol and hepatic gene expression in cholesterol-fed mice. J Oleo Sci. 2013;62(12):1049-58.
  10. Sato M, Tokuji Y, Yoneyama S, Fujii-Akiyama K, Kinoshita M, Ohnishi M. Profiling of hepatic gene expression of mice fed with edible japanese mushrooms by DNA microarray analysis: comparison among Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus. J Agric Food Chem. 2011 Oct 12;59(19):10723-31. doi: 10.1021/jf2025659. Epub 2011 Sep 12.
  11. Cui FJ, Li Y, Xu YY, Liu ZQ, Huang DM, Zhang ZC, Tao WY. Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Toxicol In Vitro. 2007 Apr;21(3):417-27. Epub 2006 Oct 13.
  12. Nishina A, Kimura H, Sekiguchi A, Fukumoto RH, Nakajima S, Furukawa S. Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK. J Lipid Res. 2006 Jul;47(7):1434-43. Epub 2006 Apr 13.
  13. Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H. Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa. Oncol Rep. 2005 Mar;13(3):497-502.
  14. Kodama N, Murata Y, Nanba H. Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. J Med Food. 2004 Summer;7(2):141-5.
  15. Jeurink PV, Noguera CL, Savelkoul HF, Wichers HJ. Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells. Int Immunopharmacol. 2008 Aug;8(8):1124-33. doi: 10.1016/j.intimp.2008.04.004. Epub 2008 May 7.
  16. Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14. doi: 10.3978/j.issn.2305-5839.2014.01.05.
  17. Ito K, Masuda Y, Yamasaki Y, Yokota Y, Nanba H. Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression. Int Immunopharmacol. 2009 Sep;9(10):1189-96. doi: 10.1016/j.intimp.2009.06.007. Epub 2009 Jun 30.
  18. Nagao M, Sato T, Akimoto N, Kato Y, Takahashi M, Ito A. Augmentation of sebaceous lipogenesis by an ethanol extract of Grifola frondosa (Maitake mushroom) in hamsters in vivo and in vitro. Exp Dermatol. 2009 Aug;18(8):730-3. doi: 10.1111/j.1600-0625.2008.00831.x. Epub 2009 Feb 18.
  19. Bae JT, Sim GS, Lee DH, Lee BC, Pyo HB, Choe TB, Yun JW. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiol Lett. 2005 Oct 15;251(2):347-54.

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These statements have not been evaluated by the FDA. This product is not intended to prevent, treat, cure, or diagnose any disease. Information on this site is for educational purposes only. It is not medical advice. Consult a physician if you are seeking medical advice or have a medical problem.