BioPerine® is a standardized black pepper fruit extract that enhances the absorption of other nutrients which support various processes in the body. Therefore, black pepper fruit extract helps the body maintain good health.

According to the BioPerine® manufacturer, “The subtle, yet potent properties of BioPerine® have been measured in several clinical studies with healthy volunteers in the U.S. These studies measured the absorption of three distinct categories of products. The categories evaluated with and without BioPerine® were fat-soluble (beta-carotene), water-soluble (vitamin B6) and a mineral (selenium, in the form of selenomethionine). Gastrointestinal absorption of all the studied nutrients, as measured by amounts present in the blood, increased dramatically when administered with BioPerine® as compared to the control group receiving the nutrient alone.”

Black Pepper Fruit has been repeatedly shown through research to:

  • Support immune system functions through its strong antioxidant activity
  • Help the body respond in a healthier manner to inflammation
  • Aid natural defenses that protect healthy cells and DNA from carcinogens and oxidative stress

Interestingly, research emphasizes that one of the main benefits of black pepper fruit is its ability to increase the absorption of additional nutrients that the body needs. For instance, optimal levels of vitamin B6, C and selenium are often observed and maintained in the body when black pepper fruit is taken regularly. This mineral also aids the absorption of nutrients in the gastrointestinal tract, which enhances metabolism and this biological process is associated with better weight support. Therefore, supplements that contain black pepper extract help the body gets the most out of the nutrients it receives.

Links to studies on Black Pepper Fruit:

  1. Chuchawankul S, Khorana N, Poovorawan Y. Piperine inhibits cytokine production by human peripheral blood mononuclear cells. Genet Mol Res. 2012 Mar 14;11(1):617-27. doi: 10.4238/2012.March.14.5.
  2. Meghwal M, Goswami TK. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. doi: 10.1002/ptr.4972. Epub 2013 Apr 29.

Other research:

  1. Misharina TA, Terenina MB, Krikunova NI. [Antioxidant properties of essential oils]. [Article in Russian] Prikl Biokhim Mikrobiol. 2009 Nov-Dec;45(6):710-6.
  2. Chonpathompikunlert P, Wattanathorn J, Muchimapura S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease. Food Chem Toxicol. 2010 Mar;48(3):798-802. doi: 10.1016/j.fct.2009.12.009. Epub 2009 Dec 23.
  3. Gülçin I. The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. Int J Food Sci Nutr. 2005 Nov;56(7):491-9.
  4. Parim B, Harishankar N, Balaji M, Pothana S, Sajjalaguddam RR. Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats. Pharm Biol. 2015 Apr 9:1-11. [Epub ahead of print]
  5. Bagheri H, Abdul Manap MY, Solati Z. Antioxidant activity of Piper nigrum L. essential oil extracted by supercritical CO₂ extraction and hydro-distillation. Talanta. 2014 Apr;121:220-8. doi: 10.1016/j.talanta.2014.01.007. Epub 2014 Jan 16.
  6. Hritcu L, Noumedem JA, Cioanca O, Hancianu M, Kuete V, Mihasan M. Methanolic extract of Piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta(1-42) rat model of Alzheimer’s disease. Cell Mol Neurobiol. 2014 Apr;34(3):437-49. doi: 10.1007/s10571-014-0028-y. Epub 2014 Jan 19.
  7. Agbor GA, Akinfiresoye L, Sortino J, Johnson R, Vinson JA. Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Food Chem. 2012 Oct 1;134(3):1354-9. doi: 10.1016/j.foodchem.2012.03.030. Epub 2012 Mar 23.
  8. Prakash B, Singh P, Mishra PK, Dubey NK. Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits. Int J Food Microbiol. 2012 Feb 1;153(1-2):183-91. doi: 10.1016/j.ijfoodmicro.2011.11.007. Epub 2011 Nov 15.
  9. Agbor GA, Vinson JA, Sortino J, Johnson R. Antioxidant and anti-atherogenic activities of three Piper species on atherogenic diet fed hamsters.Exp Toxicol Pathol. 2012 May;64(4):387-91. doi: 10.1016/j.etp.2010.10.003. Epub 2010 Oct 28.
  10. Kapoor IP, Singh B, Singh G, De Heluani CS, De Lampasona MP, Catalan CA. Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum). J Agric Food Chem. 2009 Jun 24;57(12):5358-64. doi: 10.1021/jf900642x.
  11. Vijayakumar RS, Nalini N. Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats. Cell Biochem Funct. 2006 Nov-Dec;24(6):491-8.
  12. Karthikeyan J, Rani P. Enzymatic and non-enzymatic antioxidants in selected Piper species. Indian J Exp Biol. 2003 Feb;41(2):135-40.
  13. Vijayakumar RS, Surya D, Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 2004;9(2):105-10.
  14. Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr. 2015 Jan 7. pii: S0261-5614(15)00002-3. doi: 10.1016/j.clnu.2014.12.019. [Epub ahead of print]
  15. Arcaro CA, Gutierres VO, Assis RP, Moreira TF, Costa PI, Baviera AM, Brunetti IL. Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats. PLoS One. 2014 Dec 3;9(12):e113993. doi: 10.1371/journal.pone.0113993. eCollection 2014.
  16. Teixeira BN, Ozdemir N, Hill LE, Gomes CL. Synthesis and characterization of nano-encapsulated black pepper oleoresin using hydroxypropyl beta-cyclodextrin for antioxidant and antimicrobial applications. J Food Sci. 2013 Dec;78(12):N1913-20. doi: 10.1111/1750-3841.12312.
  17. Umar S, Golam Sarwar AH, Umar K, Ahmad N, Sajad M, Ahmad S, Katiyar CK, Khan HA. Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritis. Cell Immunol. 2013 Jul-Aug;284(1-2):51-9. doi: 10.1016/j.cellimm.2013.07.004. Epub 2013 Jul 19.
  18. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 2007;47(8):735-48.
  19. Choi BM, Kim SM, Park TK, Li G, Hong SJ, Park R, Chung HT, Kim BR. Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells. J Nutr Biochem. 2007 Sep;18(9):615-22. Epub 2007 Apr 5.
  20. Rauscher FM, Sanders RA, Watkins JB 3rd. Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2000;14(6):329-34.
  21. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4.
  22. Gilhotra N, Dhingra D. Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. Pharmacol Rep. 2014 Oct;66(5):885-91. doi: 10.1016/j.pharep.2014.05.008. Epub 2014 Jun 6.
  23. Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP. Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats. Cell Mol Neurobiol. 2014 Apr;34(3):403-8. doi: 10.1007/s10571-014-0025-1. Epub 2014 Jan 9.
  24. Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP. Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice. Behav Brain Res. 2014 Mar 15;261:140-5. doi: 10.1016/j.bbr.2013.12.020. Epub 2013 Dec 19.
  25. Huang W, Chen Z, Wang Q, Lin M, Wu S, Yan Q, Wu F, Yu X, Xie X, Li G, Xu Y, Pan J. Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system. Metab Brain Dis. 2013 Dec;28(4):585-95. doi: 10.1007/s11011-013-9426-y. Epub 2013 Aug 14.
  26. Hu Y, Liao HB, Liu P, Guo DH, Wang YY. [Antidepressant effects of piperine and its neuroprotective mechanism in rats]. [Article in Chinese] Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):667-70. doi: 10.3736/jcim20090712.
  27. Bhutani MK, Bishnoi M, Kulkarni SK. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem Behav. 2009 Mar;92(1):39-43. doi: 10.1016/j.pbb.2008.10.007. Epub 2008 Oct 25.
  28. Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci. 2007 Mar 20;80(15):1373-81. Epub 2007 Jan 12.
  29. Majdalawieh AF, Carr RI. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food. 2010 Apr;13(2):371-81. doi: 10.1089/jmf.2009.1131.
  30. Liu Y, Yadev VR, Aggarwal BB, Nair MG. Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Nat Prod Commun. 2010 Aug;5(8):1253-7.
  31. Greenshields AL, Doucette CD, Sutton KM, Madera L, Annan H, Yaffe PB, Knickle AF, Dong Z, Hoskin DW. Piperine inhibits the growth and motility of triple-negative breast cancer cells. Cancer Lett. 2015 Feb 1;357(1):129-40. doi: 10.1016/j.canlet.2014.11.017. Epub 2014 Nov 13.
  32. Doucette CD, Greenshields AL, Liwski RS, Hoskin DW. Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways. Toxicol Lett. 2015 Apr 2;234(1):1-12. doi: 10.1016/j.toxlet.2015.01.020. Epub 2015 Feb 2.
  33. Kumar A, Sharma N. Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pestic Biochem Physiol. 2015 Mar;119:16-27. doi: 10.1016/j.pestbp.2015.03.003. Epub 2015 Mar 10.
  34. Kumar A, Sasmal D, Sharma N. Immunomodulatory role of piperine in deltamethrin induced thymic apoptosis and altered immune functions. Environ Toxicol Pharmacol. 2015 Mar;39(2):504-14. doi: 10.1016/j.etap.2014.12.021. Epub 2015 Jan 8.
  35. Chuchawankul S, Khorana N, Poovorawan Y. Piperine inhibits cytokine production by human peripheral blood mononuclear cells. Genet Mol Res. 2012 Mar 14;11(1):617-27. doi: 10.4238/2012.March.14.5.

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